Bio Researchers
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Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology
In a paper published in the July 24, 2009 issue of Science, researchers describe the novel application of ZFNs to generate
rats with permanent, heritable gene mutations, paving the way for the development of novel genetically modified animal models
of human disease. ZFN technology will make the generation of such animals faster and will create new opportunities in species
other than mice.
"Until now, rat geneticists lacked a viable technique for 'knocking out,' or mutating, specific genes to understand their
function," said Howard Jacob, Ph.D. Director of the Human and Molecular Genetics Center at the Medical College of Wisconsin.
"This study demonstrates that ZFN technology bypasses the current need to conduct cumbersome experiments involving nuclear
transfer (cloning) or embryonic stem cells and allows rapid creation of new animal models.
In a paper published in the July 24, 2009 issue of Science, researchers describe the novel application of ZFNs to generate
rats with permanent, heritable gene mutations, paving the way for the development of novel genetically modified animal models
of human disease. ZFN technology will make the generation of such animals faster and will create new opportunities in species
other than mice.
"Until now, rat geneticists lacked a viable technique for 'knocking out,' or mutating, specific genes to understand their
function," said Howard Jacob, Ph.D. Director of the Human and Molecular Genetics Center at the Medical College of Wisconsin.
"This study demonstrates that ZFN technology bypasses the current need to conduct cumbersome experiments involving nuclear
transfer (cloning) or embryonic stem cells and allows rapid creation of new animal models.
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